Subacute necrotizing encephalopathy in an acidotic child.

Subacute necrotizing encephalopathy in an acidotic child.

Subacute necrotizing encephalopathy was described originally by Leigh (1951). Further case reports reviewed by Ebels, Blokzijl, and Troelstra (1965) have confirmed this condition as a neuropathological entity but ideas concerning its aetiology have remained speculative. Recently Worsley, Brookfield, Elwood, Noble, and Taylor (1965) have reported a case, with confirmation at necropsy, in which t...

Impairment of pyridoxal phosphate dependent metabolic reactions in a child with subacute necrotizing encephalopathy.

Subacute necrotizing encephalomyelopathy in an infant.

K.H., a boy, aged 7 months 3 weeks, was admitted to King's College Hospital on April 22, 1947. Birth had been normal (birth weight 63 lb.) as also was development until six weeks before admission. The infant was vaccinated at the age of 2 months. He was breast-fed entirely for six weeks, then complementary feeding was begun. The baby's behaviour was normal until six weeks before admission when ...

Acute Necrotizing Encephalopathy: An Underrecognized Clinicoradiologic Disorder

Acute necrotizing encephalopathy (ANE) is a rare but distinctive type of acute encephalopathy with global distribution. Occurrence of ANE is usually preceded by a virus-associated febrile illness and ensued by rapid deterioration. However, the causal relationship between viral infections and ANE and the exact pathogenesis of ANE remain unclear; both environmental and host factors might be invol...

Infantile Subacute Necrotizing Ekcephalopathy With

Much progress has been made during the past quarter century in the clarification of the diseases encountered in the brains of newborn and young infants. In those conditions which appear to be pure degenerations of the central nervous system, however, there remains a great deal that is obscure and confused even from a descriptive or nosological standpoint. Often one seems to be dealing only with...